GINGIVAL ENLARGEMENT IN RENAL TRANSPLANT PATIENTS: A META-ANALYSIS

Gozde Serindere, Neslihan Ozveren

Abstract


Severe gingival enlargement (GE) is one of the most common observed effects in renal transplant patients due to the usage of cyclosporine A. GE causes pain, aesthetic problems, gingival bleeding and periodontal diseases. The databases of PubMed, Web of Science were searched for relevant studies from January 1990 to January 2018. Summary incidence rates, and 95% confidence intervals (CIs) were calculated by using random effects models. A total of 595 patients from 10 studies were included. The incidences of GE was 62.6% (95% CI: 41.9–79.5%) in patients using cyclosporine with or without any other drugs. Sub-group analysis according to diagnostic criteria showed that the incidence of GE was lower when a well defined diagnostic criteria or scoring system was implemented. The incidences of GE was 88.2% (95% CI: 80.9–93.0%) in patients using cyclosporine with nifedipine. Cyclosporine A without nifedipine was associated with a significantly decreased risk of GE incidence in comparison to cyclosporine A with nifedipine combination (Odds Ratio: 0.198; 95% CI, 0.083- 0.473; P < 0.001). It is important to know effects of these drugs which cause gingival enlargement and the treatment options for all clinicians. The dental evaluation in a service would be helpful for renal transplant children. The aim of this study was to gain more insight into the prevalence of gingival enlargement in renal transplant patiens.


Keywords


Gingival overgrowth; renal transplantation; cyclosporin A.

DOI: https://doi/org/10.14693/jdi.v25i2.1231

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