Is Simvastatin Associated with Oral Lichenoid Drug Reaction?

Kobkan Thongprasom


Currently, various drugs have been found to induce many oral lesions. Some medications used in the treatment of systemic diseases can affect the oral mucosa, and these lesions are known as oral lichenoid drug reaction (OLDR). The diagnosis is made when the oral lesion erupted after the patient took a specific medication. However, diagnosis is challenging when a patient takes multiple medications and the onset of the erupting oral lesions is unclear. OLDRs commonly cause severe pain in the oral cavity and affect the patient’s quality-of-life. Statins are widely used by patients with cardiovascular disease (CVD) and lower blood cholesterol levels; decreasing the risk of heart attack or stroke. This review will focus on the side-effects of a hypolipidemic drug group, the statins, in the oral cavity. From previous experience, simvastatin is a statin that may be related to severe oral ulcerations, dysplasia, and carcinoma in situ in the oral mucosa. Moreover, when simvastatin is used together with amlodipine, this combination can induce more severe oral lesions that are very difficult to treat. Therefore, the beneficial effect of these drugs and their side- effects should be carefully paid attention to because simvastatin significantly affects both oral and general health.


oral; lichenoid lesion; medication; ulceration; simvastatin

DOI: https://doi/org/10.14693/jdi.v25i3.1261

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